For Gary Holland, cannabis is a science. As the founder of Endless Cultivation, part of the larger Endless Corp., he approaches commercial growing with the same precision as a biotech firm. Every variable is measured. Every decision is data-driven. And every outcome is optimized.
"We're more of a research-driven grow," he says. "We consider ourselves a biotech company."
His approach is paying off. Endless Cultivation routinely pulls 100–150 grams per square foot, doubling or tripling industry averages.
A key factor? Precision humidity control. Stable RH eliminates stress-induced setbacks, keeping plants in prime production mode—maximizing sugar production, enhancing terpene profiles, and preventing growth stalls.
Bringing engineering discipline to cannabis
Gary's background—military, nuclear engineering, computer science—isn't what you'd expect from a commercial grower. But that's precisely why his facility runs differently. From day one, he and his team treated cannabis like a manufacturing process, not a traditional horticulture operation.
"When me and Travis, my partner, started this company, I looked at cannabis as a manufacturing company," he says. "I've been driven by science and engineering all my life."
The result? Standard operating procedures (SOPs) built around measurable, repeatable success.
The team deploys high-tech tools to track anywhere from 35 to 45 environmental parameters to fine-tune everything from light spectrums to nutrient delivery. Even widely accepted cultivation "rules" get tested—and debunked—if the data says otherwise.
One of the biggest breakthroughs at Endless Cultivation has been understanding how improper humidity control sabotages yield.
Many grows install a single oversized dehumidifier, only to watch their rooms cycle between extreme highs and lows—overcorrecting and stressing the plants. Gary says his team even saw this in their facility's previous tenant: Too much square footage being covered by too few units.
The single larger unit, Gary says, had to stay on for 10 minutes minimum to power down, and this caused big swings—65% RH down to 40% in some cases. That's cyclic stress, and it was hurting their yields.
"We went with Quest 335 units, and by doing so we can maintain a 1–2% RH variance," he says.
Instead of relying on one large unit, they opted for multiple smaller dehumidifiers, precisely balancing the water load to keep RH changes within a 1–2% window. That stability directly translates to higher yields because it eliminates the stress cycles that sap plant energy.
Why redundancy matters in dehumidification
Let's examine this issue a bit more closely. Relying on a single, oversized dehumidifier can trigger wide RH swings (due to abrupt on/off cycling) and create a single point of failure. If that unit malfunctions, your entire grow loses humidity control—potentially leading to major crop damage.
By contrast, multiple, smaller dehumidifiers (or a balanced mix of large and small units) deliver two big advantages. For one, growers see stable, even coverage across their rooms. Placing several units throughout the facility reduces hot spots and microclimates, while tighter on/off cycles keep RH from spiking or crashing.
Then there's the matter of redundancy and risk management. If one unit fails, the others continue running, preventing a total climate-control shutdown and minimizing setbacks.
One big machine might seem convenient, but distributing capacity across several dehumidifiers ensures steadier RH levels and guards against single-point failures—giving you greater peace of mind and healthier plants.
The payoff
Endless Cultivation consistently outperforms standard production metrics by optimizing climate control and eliminating unnecessary environmental stressors. They achieve 100–150 grams per square foot, which is 2–3 times the industry averages. Their terpene profiles range from 4–6%, with highs reaching 8.9%. Additionally, they employ day-to-day climate tuning to mimic real sunrise-to-afternoon shifts, enhancing overall production quality.
Their entire strategy hinges on a "maximize sugar, minimize stress" philosophy—backed by rigorous environmental monitoring and controlled experimentation.
Other large-scale growers can learn several key lessons from Endless Cultivation's approach. Firstly, it's crucial to know your water load by understanding how much water your plants transpire daily, typically between 0.5–2 pints per square foot, and size your dehumidification systems accordingly. Secondly, avoid using oversized dehumidifiers, as large, single-unit dehumidifiers can create relative humidity (RH) swings that damage yields. Instead, using multiple smaller units or a mix of large and small units helps maintain steady conditions without drastic fluctuations. Lastly, minimize stress at every stage of growth, as even minor RH swings of 5–10% can suppress terpene expression and yield potential. Maintaining stable environments is essential for better bud structure and long-term genetic stability.
Looking to the future
Endless Cultivation is always refining its growing techniques, and at the same time the company is setting the stage for the future of cannabis genetics. The company is expanding its tissue culture lab, aiming to create one of the largest cannabis biotech facilities in the country.
Eventually, Gary says, the plan is to run the largest tissue culture lab in the world, one that houses CRISPR technology to enhance its plant output.
By stabilizing genetics at the cellular level, they're working toward a future where customized cultivars can be engineered to thrive in hyper-controlled environments. And for that vision to succeed, climate stability is non-negotiable—RH, temperature, CO₂ levels, and lighting must be precision-calibrated to support high-performance genetics.
Creating a new standard in cannabis
From nuclear engineering backgrounds to CRISPR-driven breeding, the Endless approach rewrites the playbook on cannabis cultivation. Gary's team has taken a traditionally inconsistent process and turned it into a data-backed, manufacturing-grade operation—one that outperforms standard yields while paving the way for next-gen biotech applications.
For commercial cultivators, the message is clear: Dial in your environment, control your humidity, and treat every variable as a data point. In a market where efficiency and consistency determine long-term survival, that's the difference between thriving and falling behind.
"I realized cannabis was a live plant, so there's always that factor, but we treat it like a company," Gary says. "By reducing stresses and perfecting our SOPs, we're averaging 2–3 times the standard yield—that's how you thrive in this industry."
For more information:
Endless Cultivation
endlesscultivation.com/
